Abstract: In order to analyze the driving mechanism of climate factors on the transmission of dengue fever, the monthly incidence of dengue fever in Guangdong Province from 1988 to 2015 and the meteorological factors in the same period were collected. Three statistical models were used to study the relationship between meteorology and the incidence of dengue fever. The thresholds of the relationship between the minimum temperature, rainfall, relative humidity, air pressure, sunshine time and the number of dengue fever cases were 21 ℃, 50 mm, 72%, 1005 hPa, 150 h, respectively. The results show that the meteorological factors in guangdong province have a nonlinear relationship with dengue fever, and there is a lag effect. The generalized additive model was best fitting and prediction model.