• 中国期刊全文数据库
  • 中国学术期刊综合评价数据库
  • 中国科技论文与引文数据库
  • 中国核心期刊(遴选)数据库
黄小帝, 张艳菊. 基于高维特征映射的环状RNA结合蛋白位点识别方法J. 桂林电子科技大学学报, xxxx, x(x): 1-9. DOI: 10.16725/j.1673-808X.202515
引用本文: 黄小帝, 张艳菊. 基于高维特征映射的环状RNA结合蛋白位点识别方法J. 桂林电子科技大学学报, xxxx, x(x): 1-9. DOI: 10.16725/j.1673-808X.202515
HUANG XIAODI, ZHANG YANJU. Identification of CircRNA binding protein sites based on high-dimensional feature mappingJ. Journal of Guilin University of Electronic Technology, xxxx, x(x): 1-9. DOI: 10.16725/j.1673-808X.202515
Citation: HUANG XIAODI, ZHANG YANJU. Identification of CircRNA binding protein sites based on high-dimensional feature mappingJ. Journal of Guilin University of Electronic Technology, xxxx, x(x): 1-9. DOI: 10.16725/j.1673-808X.202515

基于高维特征映射的环状RNA结合蛋白位点识别方法

Identification of CircRNA binding protein sites based on high-dimensional feature mapping

  • 摘要: 环状RNA是一种具有封闭环形结构的RNA,深入分析环状RNA与结合蛋白的相互作用机制,对疾病的预防与治疗具有重要意义。然而,在环状RNA结合蛋白相互作用位点识别任务中,现有方法难以充分捕获复杂数据中的非线性关系,且缺乏高效的特征提取机制,为此提出一个新的特征提取模型HiMap-Circ,通过高维特征映射,从而提取出更加丰富和全面的特征,进而提升序列特征的表达效果和模型的整体性能。在HiMap-Circ中,使用3种不同的编码方式对环状RNA序列进行特征编码,并结合高维特征映射、多尺度卷积以及注意力机制进行特征融合,从而捕获序列中的局部与全局特征。在环状RNA数据集上与其他同类方法进行对比实验以及消融实验,结果表明,HiMap-Circ优于现有最先进的同类方法,证明该方法是预测环状RNA与结合蛋白的相互作用位点的有效方法。

     

    Abstract: CircRNA is a kind of RNA with a closed ring structure, and in-depth analysis of the interaction mechanism between CircRNA and binding proteins is of great significance for disease prevention and treatment. However, in the task of identifying the interaction sites of CircRNA binding proteins, it is difficult for the existing methods to adequately capture the nonlinear relationships in the complex data and lack of efficient feature extraction mechanisms, for this reason, we propose a new feature extraction model, HiMap-Circ, which can extract richer and more comprehensive features through feature high-dimensional mapping, thus improving the expression effect of the sequence features and overall model performance. In HiMap-Circ, three different encoding methods are used to encode features in CircRNA sequences, and feature fusion is performed by combining feature high-dimensional mapping, multi-scale convolution, and the attention mechanism, so as to capture both local and global features in the sequences. Comparison experiments with other similar methods on CircRNA datasets as well as ablation experiments show that HiMap-Circ outperforms the existing state-of-the-art similar methods and proves to be an effective method for predicting the interaction sites of CircRNA with binding proteins.

     

/

返回文章
返回